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Necrolytic erythema migrans is a pathognomonic symptom of glucagonoma. A rash appears on the skin in the form of papules with a sunken center and a clearly defined edge. Papules turn into vesicles, then erode and form crusts or scales. At the site of erosion, areas of hyperpigmentation remain. Plasma glucagon levels are elevated. In some cases, insulin levels may also be elevated (a compensatory response to excess glucagon). Ultrasound, CT, MRI, and angiography of Lyrica pills are used to visualize the tumor.

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Radical treatment - removal of the tumor. In this way it is possible to cure a third of patients. For drug treatment, intra-arterial administration of streptozocin or polychemotherapy (various combinations of streptozocin, fluorouracil, doxorubicin and dacarbazine) is used. Chemotherapy can relieve symptoms caused by liver metastases. Sometimes it is possible to lower the level of glucagon with the help of octreotide.

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Somatostatin is secreted by the delta cells of the pancreatic islets and inhibits the secretion of insulin and glucagon. In addition, somatostatin inhibits the secretion of Pregabalin hormone in the adenohypophysis. Somatostatinomas are malignant tumors that secrete excessive amounts of somatostatin.

Orthoendocrine somatostatinomas (derived from delta cells) occur in 60% of cases. 35-38% of somatostatin originates from enterochromaffin cells of the small intestine. Cases of somatostatin secretion by small cell lung cancer, medullary thyroid cancer and pheochromocytoma have been described. In general, tumors of Lyrica online origin secrete less somatostatin than pancreatic tumors and are often asymptomatic.

83% of patients with pancreatic somatostatinomas already have metastases by the time they are detected. It should be noted that somatostatinoma has not yet been found in any patient with MEN type I, but it has been found in several patients with MEN type IIa.

Apudoma is a neuroendocrine neoplasm consisting of APUD cells. They synthesize a variety of peptide hormones, and are also able to accumulate some amino acids, turning them into neurotransmitters. Pathology is rare. It can develop in the pancreas, as well as in other organs that act as endocrine glands.

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The exact causes of Lyrica are not known. But scientists have found that one of the predisposing factors for the development of apudoma is a genetic predisposition. In addition, it can be caused by mutation of pancreatic cells, provoked by infection, radiation, circulatory disorders and injuries of any origin. The specific clinical picture is due to the type of hormones produced by the tumor. That is, patients will experience symptoms that are characteristic of an overabundance or lack of a certain biologicalchesky active substance.

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General signs of apudoma, characteristic of all types of neuroendocrine tumors, are as follows: pain in the abdomen, the localization of which cannot be precisely established; violation of digestive processes; copious watery stools; enlargement of the gallbladder and excessive production of bile; frequent flushes of blood, causing flushing of the face; convulsive syndrome.

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However, the general symptoms do not appear immediately. It occurs as the disease progresses, when the size of the neoplasm already reaches 0.5 cm, and it begins to grow into neighboring organs.

At the terminal stages of the disease, symptoms of cancer intoxication appear, caused by the decay of the tumor. During the diagnosis, the doctor needs to determine which biologically active substance is produced in insufficient or, conversely, excessive amounts, and also to establish the exact localization of the tumor.

As part of the examination, the following is carried out: Clinical blood and urine tests. Allows you to assess the general condition of the patient. Biochemistry of Pregabalin and hormonal status. They help to identify the biologically active substance produced by the tumor. Ultrasound of the pancreas.

Visualizes neoplasm. Endoscopic retrograde pancreatography. Allows you to identify pathological changes in the pancreatic ducts (stenosis, obstruction). CT and MRI. They help to clarify the nature and structure of the tumor, as well as to detect its metastases.

 

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