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Overview: Dicyclomine is used to treat irritable bowel syndrome (IBS). It works by relaxing muscles in the gut, which helps reduce spasms or cramping. Common side effects include dizziness, dry mouth, blurred vision, nausea, and sleepiness. It should not be used if you have certain medical conditions, such as glaucoma, a blockage of the gut or urinary tract, or severe ulcerative colitis. Do not drive or do other activities that require alertness or coordination until you know how dicyclomine affects you. Dicyclomine comes as a capsule, liquid, or tablet that is taken by mouth, or an injectable form given by a health care provider.

Uses

What is dicyclomine used for?

Dicyclomine is commonly used to treat irritable bowel syndrome (IBS).

Dicyclomine may also be used for other conditions as determined by your health care provider.

How does dicyclomine work (mechanism of action)?

Dicyclomine helps relieve belly spasms and cramps by relaxing the gut muscles.

How is dicyclomine supplied (dosage forms)?

Brands and other names

  • Bentyl 

Dosage forms and strengths

  • 10 mg oral capsules
  • 20 mg, 40 mg oral tablets
  • 10 mg/5 mL oral liquid

Dicyclomine is also available in an injectable form.

How should I store dicyclomine?

Dicyclomine should be stored at room temperature, between 68 F and 77 F (20 C and 25 C). It can be exposed to temperatures between 59 F and 86 F (15 C and 30 C), for shorter periods of time, such as when transporting it. Store in a cool, dry place. Protect from light and from excessive heat or freezing.

Side Effects

What are the most common side effects of dicyclomine?

The most common side effects of dicyclomine are listed below. Tell your health care provider if you have any of these side effects that bother you.

  • Dizziness
  • Dry mouth
  • Blurred vision
  • Nausea
  • Sleepiness
  • Feeling unusually weak or tired
  • Nervousness

There may be other side effects of dicyclomine that are not listed here. Contact your health care provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088 (800-332-1088). In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.

What are the serious side effects of dicyclomine?

While less common, the most serious side effects of dicyclomine are described below, along with what to do if they happen.

Nervous System Effects. Dicyclomine may affect parts of the nervous system. It can also cause you to sweat less, which may lead to fever or heatstroke in high temperatures. Call your health care provider right away if you have any of the following symptoms.

  • Dry mouth and trouble swallowing, talking, or peeing 
  • Increased thirst
  • Dry skin or flushing
  • Dilated pupils and sensitivity to light
  • Changes in your heartbeat or heart rhythm
  • Constipation
  • Confusion or disorientation
  • Memory problems
  • Seeing or hearing things that others do not see or hear
  • Trouble speaking
  • Trouble with balance or coordination
  • A feeling of intense excitement and happiness
  • Tiredness
  • Trouble sleeping
  • A feeling of restlessness

Severe Allergic Reactions. Dicyclomine may cause allergic reactions, which can be serious. Stop taking dicyclomine and get help right away if you have any of the following symptoms of a serious allergic reaction.

  • Breathing problems or wheezing
  • Racing heart
  • Fever or general ill feeling
  • Swollen lymph nodes
  • Swelling of the face, lips, mouth, tongue, or throat
  • Trouble swallowing or throat tightness
  • Itching or skin rash
  • Bumps on the skin called hives that can be red, pink, white, or brown depending on your skin tone
  • Nausea or vomiting
  • Dizziness, feeling lightheaded, or fainting
  • Stomach cramps
  • Joint pain

Warnings & Precautions

Who should not use dicyclomine?

Allergies to Ingredients. People who are allergic to any of the following should not use dicyclomine.

  • Bentyl
  • Dicyclomine
  • Any of the ingredients in the specific product dispensed

Your pharmacist can tell you all of the ingredients in the specific dicyclomine products they stock.

Infants Under 6 Months of Age. Giving dicyclomine to infants under 6 months has led to cases of severe breathing problems, seizures, fainting, changes in heart rate, muscle weakness, coma, and death. Dicyclomine should not be used in infants under 6 months.

Breastfeeding. Do not use dicyclomine if you are breastfeeding. You must either stop breastfeeding or stop dicyclomine. See the Breastfeeding section for more details.

Myasthenia Gravis. Myasthenia gravis is a condition that can cause muscle weakness. Dicyclomine can make this condition worse. 

Glaucoma. Glaucoma is a condition that may lead to trouble seeing or blindness because of damage to the optic nerve in your eye. Dicyclomine may make this condition worse or can block the effects of medicines used to treat glaucoma. It should not be used if you have glaucoma.

Blockage of the Urinary Tract. Dicyclomine should not be used if you have a blockage in your urinary tract, also called obstructive uropathy. Dicyclomine can make this condition worse. 

Blockage of the Gut. Dicyclomine should not be used if you have a blockage of your gut. Dicyclomine can make this worse.

Severe Ulcerative Colitis. Ulcerative colitis is an inflammatory bowel disease that can cause pain and sores in the lining of your large intestine. Dicyclomine should not be used if you have severe ulcerative colitis. It may slow down the movement in your gut and lead to problems such as severe swelling or a hole in the intestines.  

Inflammation of the Esophagus Due To Acid Reflux. Acid reflux can lead to inflammation of the esophagus, sometimes called reflux esophagitis. Dicyclomine should not be used if you have reflux esophagitis.

What should I know about dicyclomine before using it?

Do not use dicyclomine unless it has been prescribed to you by a health care provider. Use it as prescribed.

Do not share dicyclomine with other people, even if they have the same condition as you. It may harm them.

Keep dicyclomine out of the reach of children.

Dicyclomine may affect your alertness or coordination. It can also cause blurred vision, dizziness, or drowsiness. Do not drive or do other activities that require alertness or coordination until you know how dicyclomine affects you.

People who are age 65 and older can be at greater risk for some side effects from dicyclomine. Talk to your health care provider about your risks if you are in this age group.

If you are taking dicylomine oral lquid, use an accurate measuring device to measure your dose. A household spoon is not an accurate measuring device and may cause you to take the wrong dose. Ask your pharmacist what measuring device to use.

What should I tell my health care provider before using dicyclomine?

Tell your health care provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them know if dicyclomine is right for you.

In particular, make sure that you discuss any of the following.

Current and Past Health Conditions. Tell your health care provider if you have any of the following.

Heart Conditions or a Fast Heartbeat. Tell your health care provider if you have a history of a fast or irregular heartbeat. Also tell your doctor if you have heart failure, heart disease, or too much thyroid hormone. Dicyclomine may cause a fast or irregular heartbeat or palpitations, which may worsen some of these conditions.

Nerve Damage. Tell your health care provider if you have a condition called autonomic neuropathy, which is caused by nerve damage. Dicyclomine can affect certain nerves in your body, and it should be used cautiously if you have autonomic neuropathy.

Partial Blockage of the Gut. Tell your health care provider if you have a partial blockage of your gut, or if you have an ileostomy or colostomy (openings made in the intestines to collect poo). Dicyclomine should not be used and may be harmful if you have a gut blockage. 

Infectious Diarrhea. Tell your health care provider if you have a stomach infection or food-related illness. Using dicyclomine while you have an illness from certain bacteria, sometimes called salmonella dysentery, may lead to severe swelling or a hole in the intestines.  

Mental Health Problems. Tell your health care provider about any mental health problems you have had, especially if you have had symptoms such as losing touch with reality (psychosis) or seeing, hearing, or believing things that aren’t real, also called hallucinations.

Other Medicines and Supplements. Dicyclomine may interact with other medicines and supplements. Before using dicyclomine, tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. See the Interactions section below for more details.

Pregnancy. It is not known if or how dicyclomine could affect pregnancy or harm a fetus. It should be used during pregnancy only if clearly needed. Tell your health care provider if you are or plan to become pregnant. 

Breastfeeding. Dicyclomine passes into breast milk and may harm a breastfed infant. Tell your health care provider if you are breastfeeding or plan to breastfeed. Your health care provider will let you know if you should stop dicyclomine or stop breastfeeding. 

Interactions

Does dicyclomine interact with foods or drinks?

There are no known interactions between dicyclomine and foods or drinks. 

It is unknown if drinking alcohol will affect dicyclomine. The risk of dizziness, blurred vision, or sleepiness may be increased if you drink alcohol while using dicyclomine.

Does dicyclomine interact with other medicines (drug interactions)?

Always tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.

In particular, make sure that you discuss if you are using any of the following before using dicyclomine.

  • Any other medicine that causes dizziness and sleepiness (e.g., prescription pain medicines, sleep medicines, and medicines for anxiety)
  • A medicine used to treat an eye condition called glaucoma
  • An anticholinergic medicine, which includes antihistamines and certain medicines for overactive bladder, Parkinson’s disease, stomach problems, motion sickness, and others
  • An antacid, which is a medicine that neutralizes the acid in your stomach to relieve indigestion and heartburn, such as calcium carbonate or magnesium hydroxide
  • A medicine that affects motility in the gut, such as metoclopramide (Reglan, Gimoti)

Dicyclomine may affect the absorption of some other medicines. Tell your health care provider about all medicines that you take or have recently taken.

This may not be a complete list of medicines that can interact with dicyclomine. Always check with your health care provider.

Does interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose/Missed Dose

What should I do if I accidentally use too much dicyclomine?

If you or someone else has used too much dicyclomine, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.

What should I do if I miss a dose of dicyclomine?

If you miss a dose, skip the missed dose and only use the next dose. Do not use double or extra doses.